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M9470005.TXT
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1994-07-02
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Document 0005
DOCN M9470005
TI Human cytomegalovirus replication correlates with differentiation in a
hematopoietic progenitor cell line and can be modulated by HIV-1.
DT 9409
AU Lazzarotto T; Furlini G; Re MC; Ramazzotti E; Campisi B; Landini MP;
Institute of Microbiology, University of Bologna, Italy.
SO Arch Virol. 1994;135(1-2):13-28. Unique Identifier : AIDSLINE
MED/94256831
AB Human cytomegalovirus (HCMV) infection of a CD34+ hematopoietic
progenitor cell line (TF1) was studied before and after TPA
differentiation. TF1 cells were found to be infected but the virus does
not replicate, while differentiated TF1 cells can be infected and allow
HCMV complete replication. In the same system we studied the interaction
between HCMV and HIV and found that while contact between HIV gp 120 and
the HCMV-infected cell has an inhibitory effect, exogenous Tat protein
stimulates HCMV replication. The interaction between HCMV and HIV in
hematopoietic progenitor cells is complex and depends on several factors
that can have opposite effects.
DE Antigens, CD/ANALYSIS Antigens, Viral/ANALYSIS *Cell
Differentiation/DRUG EFFECTS Cell Line
Cytomegalovirus/GENETICS/*PHYSIOLOGY DNA, Viral/ANALYSIS Fluorescent
Antibody Technique Gene Products, tat/METABOLISM Genome, Viral
Hematopoietic Stem Cells Human HIV Core Protein p24/ANALYSIS HIV
Envelope Protein gp120/METABOLISM HIV-1/GENETICS/*PHYSIOLOGY Kinetics
Polymerase Chain Reaction Recombinant Proteins/METABOLISM Support,
Non-U.S. Gov't Tetradecanoylphorbol Acetate/PHARMACOLOGY *Virus
Replication JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).